[Four cases of Hodgkin's disease treated with MOPP/ABV hybrid regimen using nitrogen mustard-N-oxide hydrochloride].

Abstract

Four patients with fresh Hodgkin's disease were treated with MOPP/ABV hybrid regimen using nitrogen mustard-N-oxide hydrochloride (NH2-O). All patients responded well to this therapy and achieved complete remission. Toxicity was minimum except for an older patient. He was 70 years old and developed arrhythmia after MOPP therapy but recovered without any treatment. The continuation of therapy was possible by dose reduction in this case. We conclude MOPP/ABV regimen using NH2-O is valuable for the treatment of Hodgkin's disease.

• Authors: Y Kozai, T Ohyama, H Kodo, G Tomori
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 19 Issue 14 Pg. 2407-9 (Dec 1992) ISSN: 0385-0684 [Print] Japan
• PMID: 1281397 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Bleomycin
• Procarbazine
• Mechlorethamine
• Vincristine
• Vinblastine
• Doxorubicin
• Prednisone

Topics

• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage)
• Doxorubicin (administration & dosage)
• Drug Administration Schedule
• Female
• Hodgkin Disease (drug therapy)
• Humans
• Male
• Mechlorethamine (administration & dosage)
• Middle Aged
• Prednisone (administration & dosage)
• Procarbazine (administration & dosage)
• Remission Induction
• Vinblastine (administration & dosage)
• Vincristine (administration & dosage)