HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

High-frequency ventilation in the pediatric intensive care unit.

AbstractOBJECTIVE:
To provide a state-of-the-art review of high-frequency oscillatory ventilation in the management of pediatric patients with respiratory failure.
DATA SOURCES:
A thorough analysis of the preclinical and clinical literature regarding the pathophysiology of respiratory failure and the efficacy of high-frequency techniques in the neonatal and pediatric populations.
DATA SYNTHESIS:
After an overview of the introduction of high-frequency techniques, the following topical areas are addressed: device vs. strategy, indications for use, disease-specific strategies, additional practical considerations, and the future of high-frequency techniques.
CONCLUSIONS:
The ideal ventilatory approach in patients with hypoxemic respiratory failure may be early institution of an "open lung" strategy using high-frequency ventilatory techniques. The mechanisms of gas exchange that are most important during high-frequency ventilation are bulk axial flow, interregional gas mixing, and molecular diffusion. Infants with hyaline membrane disease and congenital diaphragmatic hernia have also responded positively to the implementation of high-frequency techniques. The oxygenation index (mean airway pressure x Fio2 x 100/Pao2) provides useful prognostic information in patients being managed with high-frequency oscillatory ventilation and may help to identify those patients with high predicted mortality to offer additional or experimental therapies. In the future, the combination of high-frequency oscillatory ventilation and partial liquid breathing offers the possibility of partitioning the physiologic changes associated with positive pressure ventilation. This approach may prove to be the ultimate lung-protective ventilatory strategy.
AuthorsJ H Arnold
JournalPediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies (Pediatr Crit Care Med) Vol. 1 Issue 2 Pg. 93-9 (Oct 2000) ISSN: 1529-7535 [Print] United States
PMID12813257 (Publication Type: Journal Article)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: