MR imaging and spectroscopy of a tuber cinereum hamartoma in a patient with growth hormone deficiency and hypogonadotropic hypogonadism.

Abstract

To our knowledge, this is the first report of hypogonadotropic hypogonadism, or growth hormone deficiency, in a patient without non-Pallister-Hall syndrome who had hypothalamic hamartoma diagnosed on the basis of MR imaging and MR spectroscopy findings. On short-TE proton MR spectra, the N-acetylaspartate concentration in the hamartoma was lower than that in the thalamus but similar to that in the amygdala. However, myo-inositol concentration was elevated in the hamartoma compared with that in the amygdala and thalamus. This report stresses the advantages of short-TE spectroscopy and demonstrates that regional variations in spectra should be considered when reference structures are used.

• Authors: David D Martin, Uwe Seeger, Michael B Ranke, Wolfgang Grodd
• Journal: AJNR. American journal of neuroradiology (AJNR Am J Neuroradiol) 2003 Jun-Jul Vol. 24 Issue 6 Pg. 1177-80 ISSN: 0195-6108 [Print] United States
• PMID: 12812950 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Gonadotropins, Pituitary
• Human Growth Hormone
• Aspartic Acid
• Inositol
• N-acetylaspartate
• Creatine
• Choline

Topics

• Adolescent
• Amygdala (pathology)
• Aspartic Acid (analogs & derivatives, analysis)
• Choline (analysis)
• Creatine (analysis)
• Diagnosis, Differential
• Gonadotropins, Pituitary (deficiency)
• Hamartoma (congenital, diagnosis)
• Human Growth Hormone (deficiency)
• Humans
• Hypogonadism (diagnosis)
• Hypothalamic Diseases (congenital, diagnosis)
• Inositol (analysis)
• Magnetic Resonance Imaging
• Magnetic Resonance Spectroscopy
• Male
• Thalamus (pathology)
• Tuber Cinereum (pathology)