Abstract | OBJECTIVE: METHODS: Immunohistochemistry was used to examine the expression of RANTES and MIP-1alpha in the specimens of labial gland of 14 cases of primary SS, 7 cases of secondary SS (sSS), and 8 cases of controls, including maxillofacial injury and lip cyst. RESULTS: The expression rate of RANTES was 86% (12/14) in the pSS group and 71% (10/14) in the sSS group, and was 0 in the control group (P < 0.01). The expression rate of MIP-1alpha was 86% (5/7) in the pSS group, 71% (5/7) in the sSS group, and 25% (2/8) in the control group (P > 0.05). The RANTES and MIP-1alpha were expressed in the cytoplasm of ductal epithelium and part of infiltrated lymphocytes. The positive expression of RANTES was more evident than that of MIP-1alpha. CONCLUSION:
RANTES and MIP-1alpha may attract the circulating lymphocytes towards inflammation site of labial gland so as play a crucial role in the pathogenesis of SS etiopathology.
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Authors | Fang Wang, Zhen-gang Wang, Fu-lin Tang |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 83
Issue 3
Pg. 220-3
(Feb 10 2003)
ISSN: 0376-2491 [Print] China |
PMID | 12812666
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Chemokine CCL3
- Chemokine CCL4
- Chemokine CCL5
- Macrophage Inflammatory Proteins
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Topics |
- Adult
- Chemokine CCL3
- Chemokine CCL4
- Chemokine CCL5
(analysis, biosynthesis)
- Endothelium
(chemistry)
- Female
- Humans
- Immunohistochemistry
- Lip
- Macrophage Inflammatory Proteins
(analysis, biosynthesis)
- Male
- Middle Aged
- Salivary Glands, Minor
(metabolism)
- Sjogren's Syndrome
(metabolism)
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