[Change in indicators of metabolism and kidney function in intact rats after parenteral administration of sodium hypochlorite].

Abstract

The changes of kidney metabolism, function and enzymuria activity of nephron epithelium cells after 4 days of parenteral administration of sodium hypochlorite 0.02% and 0.06% solutions were investigated in the experiments on 15 intact non-inbred rats of 200-280 g body weight. It was revealed that sodium hypochlorite induced metabolic damage to the kidney similar to ischemic one. The 0.02 and 0.06% solutions of sodium hypochlorite administered parenterally produced no negative effect on renal function. There was no significant rise of enzymuria activity in experimental groups compared to the controls. Moreover, enzymuria of four from six nephron epithelium cell enzymes decreased significantly to day 5 of the experiment. Metabolic damage and enzymuria activity changes were more pronounced in rats given parenteral 0.06% solution of sodium hypochlorite.

• Authors: V I Kirpatovskiĭ, A P Danilkov, V V Ivashchenko, S A Salmanov, Iu V Kudriavtsev, S A Golovanov, V V Drozhzheva, L A Mikheeva, T A Boĭko, E V Syromiatnikova
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2003 Mar-Apr Issue 2 Pg. 28-32 ISSN: 1728-2985 [Print] Russia (Federation)
• Vernacular Title: Izmenenie pokazateleĭ metabolizma i funktii pochek u intaktnykh krys posle parenteral'nogo vvedeniia gipokhlorita natriia.
• PMID: 12811922 (Publication Type: English Abstract, Journal Article)

Chemical References

• Sodium Hypochlorite

Topics

• Animals
• Injections, Intraperitoneal
• Kidney (drug effects, enzymology, metabolism, physiology)
• Kidney Function Tests
• Rats
• Sodium Hypochlorite (administration & dosage)