Abstract | OBJECTIVE: METHODS: Single photon emission computed tomography scans were performed in 14 patients with liver cirrhosis before and after the administration of branched-chain amino acids in a single-day split-dose protocol. The per cent change in regional brain perfusion was calculated in high frontal, parietal, temporal, occipital lobes and cerebellum. Thereafter, statistical parametric mapping was performed to identify brain regions with abnormal cerebral perfusion. RESULTS:
Intravenous infusion of solutions enriched with branched-chain amino acids induced a 13-20% increase in regional cerebral blood flow. Cirrhotic patients had regions of significant hypoperfusion, as determined by statistical parametric mapping, in the left superior parietal and posterior cingulate as compared to the control group. This hypoperfusion of parietal and cingulate regions was not detected after treatment with solutions of branched-chain amino acids. CONCLUSIONS:
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Authors | Motoh Iwasa, Kaname Matsumura, Yuri Watanabe, Mika Yamamoto, Masahiko Kaito, Jiro Ikoma, Esteban C Gabazza, Kan Takeda, Yukihiko Adachi |
Journal | European journal of gastroenterology & hepatology
(Eur J Gastroenterol Hepatol)
Vol. 15
Issue 7
Pg. 733-7
(Jul 2003)
ISSN: 0954-691X [Print] England |
PMID | 12811303
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Amino Acids, Branched-Chain
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Topics |
- Aged
- Amino Acids, Branched-Chain
(therapeutic use)
- Brain
(diagnostic imaging)
- Cerebrovascular Circulation
(drug effects, physiology)
- Female
- Hepatic Encephalopathy
(diagnostic imaging, drug therapy, etiology)
- Humans
- Infusions, Intravenous
- Liver Cirrhosis
(complications, diagnostic imaging, physiopathology)
- Male
- Middle Aged
- Tomography, Emission-Computed, Single-Photon
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