Abstract |
The translocation between chromosomes 2 and 8, t(2;8), is well known for its strong association with high-grade Burkitt lymphoma. However, the significance of this translocation in indolent lymphoproliferative disorders is not clear. We present the case of a 75-year-old white male with left upper quadrant abdominal pain, splenomegaly, and an elevated white cell count of 30.3x10(9) cells/L (84% large lymphoid cells with scanty cytoplasm and prominent central nucleoli). Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface lambda. The cytogenetic analysis showed all 20 cells with t(2;8)(p12;q24.3). In addition, four of the 20 cells also showed a second translocation: t(12;17)(p13;q21). Molecular analysis using c-myc and p53 probes showed normal results with no indication of amplification of C-MYC or deletion of TP53. The patient was managed as an indo-lent/low-grade lymphoproliferative disorder with excellent response to eight cycles of fludarabine.
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Authors | Anil Potti, Amit Panwalkar, Mark C Ingebretson, Sugandhi A Tharapel, Michael Goodell, M V Dayton, Syed A Mehdi |
Journal | Cancer genetics and cytogenetics
(Cancer Genet Cytogenet)
Vol. 144
Issue 1
Pg. 76-9
(Jul 01 2003)
ISSN: 0165-4608 [Print] United States |
PMID | 12810261
(Publication Type: Case Reports, Journal Article)
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Topics |
- Aged
- Chromosomes, Human, Pair 2
- Chromosomes, Human, Pair 8
- Gene Amplification
- Genes, myc
- Genes, p53
- Humans
- Immunophenotyping
- In Situ Hybridization, Fluorescence
- Karyotyping
- Lymphoma, B-Cell
(diagnostic imaging, genetics)
- Male
- Tomography, X-Ray Computed
- Translocation, Genetic
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