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An indolent B-cell lymphoma with t(2;8)(p12;q24) abnormality and absence of C-MYC amplification and TP53 deletion. A new variant?

Abstract
The translocation between chromosomes 2 and 8, t(2;8), is well known for its strong association with high-grade Burkitt lymphoma. However, the significance of this translocation in indolent lymphoproliferative disorders is not clear. We present the case of a 75-year-old white male with left upper quadrant abdominal pain, splenomegaly, and an elevated white cell count of 30.3x10(9) cells/L (84% large lymphoid cells with scanty cytoplasm and prominent central nucleoli). Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface lambda. The cytogenetic analysis showed all 20 cells with t(2;8)(p12;q24.3). In addition, four of the 20 cells also showed a second translocation: t(12;17)(p13;q21). Molecular analysis using c-myc and p53 probes showed normal results with no indication of amplification of C-MYC or deletion of TP53. The patient was managed as an indo-lent/low-grade lymphoproliferative disorder with excellent response to eight cycles of fludarabine.
AuthorsAnil Potti, Amit Panwalkar, Mark C Ingebretson, Sugandhi A Tharapel, Michael Goodell, M V Dayton, Syed A Mehdi
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 144 Issue 1 Pg. 76-9 (Jul 01 2003) ISSN: 0165-4608 [Print] United States
PMID12810261 (Publication Type: Case Reports, Journal Article)
Topics
  • Aged
  • Chromosomes, Human, Pair 2
  • Chromosomes, Human, Pair 8
  • Gene Amplification
  • Genes, myc
  • Genes, p53
  • Humans
  • Immunophenotyping
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Lymphoma, B-Cell (diagnostic imaging, genetics)
  • Male
  • Tomography, X-Ray Computed
  • Translocation, Genetic

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