Abstract | BACKGROUND: RESULTS: In animals undergoing ischemia-reperfusion injury, neuropathological and ultrastructural changes were monitored for 1-7 days either in the presence or in the absence of M40401 after bilateral common carotid artery occlusion (BCCO). Administration of M40401 (1-40 mg/kg, given i.p. 1 h after BCCO) protected against post-ischemic, ultrastructural and neuropathological changes occurring within the hippocampal CA1 area. The protective effect of M40401 was associated with a significant reduction of the levels of malondialdehyde (MDA; a marker of lipid peroxidation) in ischemic brain tissues after ischemia-reperfusion. CONCLUSION: Taken together, these results demonstrate that M40401 provides protective effects when given early after the induction of ischemia-reperfusion of brain tissues and suggest the possible use of such compounds in the treatment of neurological dysfunction subsequent to cerebral flow disturbances.
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Authors | Vincenzo Mollace, Michelangelo Iannone, Carolina Muscoli, Ernesto Palma, Teresa Granato, Andrea Modesti, Robert Nisticò, Domenicantonio Rotiroti, Daniela Salvemini |
Journal | BMC pharmacology
(BMC Pharmacol)
Vol. 3
Pg. 8
(Jun 16 2003)
ISSN: 1471-2210 [Electronic] England |
PMID | 12809567
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- M40401
- Organometallic Compounds
- Protective Agents
- Malondialdehyde
- Superoxide Dismutase
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Topics |
- Animals
- Brain Ischemia
(complications)
- Disease Models, Animal
- Gerbillinae
- Male
- Malondialdehyde
(metabolism)
- Organometallic Compounds
(therapeutic use)
- Protective Agents
(therapeutic use)
- Reperfusion Injury
(metabolism, prevention & control)
- Superoxide Dismutase
(chemistry)
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