An open label, multicenter, non-comparative study of the efficacy and safety of oral gatifloxacin in the treatment of community-acquired pneumonia: a Brazilian study in five centers.

We made an open label, multicenter, non-comparative study to assess the efficacy and safety of oral gatifloxacin, 400 mg PO given once-daily during 7 to 14 days for the treatment of adult outpatients with community-acquired pneumonia at five Brazilian medical facilities. Among the 86 subjects available for clinical evaluation, 84 (98%) were cured. The bacteriological eradication and presumed eradication rate was 98% (52/53) among the 44 (51%) patients who were bacteriologically evaluated. Drug-related adverse events were reported by 27% of the patients, diarrhea being the most frequent, occurring in 12% of patients. Adverse events were considered mild (89%) or moderate (11%). We conclude that a 7-14 day course of gatifloxacin, 400 mg PO given once daily is safe and effective for the treatment of community-acquired pneumonia. The drug had a favorable safety profile and a good clinical and bacteriological efficacy.
AuthorsAntônio Carlos Nicodemo
JournalThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases (Braz J Infect Dis) Vol. 7 Issue 1 Pg. 62-8 (Feb 2003) ISSN: 1413-8670 [Print] Brazil
PMID12807692 (Publication Type: Journal Article, Multicenter Study)
Chemical References
  • Anti-Infective Agents
  • Fluoroquinolones
  • gatifloxacin
  • Administration, Oral
  • Adolescent
  • Adult
  • Anti-Infective Agents (administration & dosage, adverse effects)
  • Brazil
  • Community-Acquired Infections (drug therapy, microbiology)
  • Female
  • Fluoroquinolones
  • Haemophilus influenzae (drug effects)
  • Humans
  • Male
  • Pneumonia, Bacterial (drug therapy, microbiology)
  • Streptococcus pneumoniae (drug effects)
  • Treatment Outcome

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