Abstract |
Short-term effects of alacepril, an angiotensin-converting enzyme inhibitor (ACEI), on renal function and hemodynamics were investigated in 10 hypertensive subjects (aged 55.7 +/- 9.5 years, mean +/- SD). Renal plasma flow (RPF) and glomerular filtration rate (GFR) were examined before and after 12-week administration of alacepril, by [131I]hippuran and [99mTc] DTPA, respectively. Alacepril (50 mg/day) caused a significant decrease in both systolic and diastolic blood pressure (SBP and DBP, from 161 +/- 8 to 140 +/- 10 mm Hg and from 100 +/- 3 to 90 +/- 5 mm Hg, respectively). Alacepril increased GFR (from 63.4 +/- 22.2 to 69.1 +/- 22.1 ml/min/1.73 m2, p less than 0.05) without changing RPF (from 438 +/- 194 to 432 +/- 148 ml/min/1.73 m2, p greater than 0.05). Serum creatinine and electrolytes were not changed by alacepril administration. These data show that short-term alacepril administration improves renal function, probably owing to relaxation of renal vasoconstriction.
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Authors | K Tomita, H Nonoguchi, Y Terada, F Marumo |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 20
Issue 4
Pg. 520-4
(Oct 1992)
ISSN: 0160-2446 [Print] United States |
PMID | 1280705
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Electrolytes
- Captopril
- Creatinine
- alacepril
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Topics |
- Adult
- Aged
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Blood Pressure
(drug effects)
- Captopril
(analogs & derivatives, pharmacology)
- Creatinine
(blood)
- Electrolytes
(blood)
- Female
- Glomerular Filtration Rate
(drug effects)
- Hemodynamics
(drug effects)
- Humans
- Hypertension
(drug therapy)
- Kidney
(drug effects)
- Kidney Function Tests
- Male
- Middle Aged
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