Abstract | OBJECTIVE: METHODS: RESULTS: During the first week, the right ventricle showed no significant change in 1,2-diacylglycerol content and a small increase in RNA concentration. However, the 1,2-diacylglycerol content was significantly increased by 55% at two weeks after monocrotaline injection, when DNA and RNA synthesis was also enhanced to its highest level when compared with control rats (37% and 18%, respectively). At four weeks after monocrotaline injection, conversely, the 1,2-diacylglycerol content was decreased by 25% in the right ventricle from monocrotaline treated rats, most of which had pleural and peritoneal effusions indicating congestive heart failure, although RNA synthesis was sustained at a high level. The fatty acid composition of 1,2-diacylglycerol did not differ significantly between the right and left ventricles or control rat ventricles. CONCLUSIONS:
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Authors | K Okumura, J Kondo, K Shimizu, M Yoshino, Y Toki, H Hashimoto, T Ito |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 26
Issue 6
Pg. 626-30
(Jun 1992)
ISSN: 0008-6363 [Print] England |
PMID | 1280532
(Publication Type: Journal Article)
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Chemical References |
- 1,2-diacylglycerol
- Diglycerides
- Fatty Acids
- RNA
- Monocrotaline
- DNA
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Topics |
- Animals
- Cardiomegaly
(chemically induced, metabolism)
- DNA
(metabolism)
- Diglycerides
(metabolism)
- Fatty Acids
(metabolism)
- Heart Failure
(chemically induced, metabolism)
- Heart Ventricles
- Hypertension, Pulmonary
(chemically induced)
- Lipid Metabolism
- Male
- Monocrotaline
(pharmacology)
- Myocardium
(metabolism)
- Osmolar Concentration
- RNA
(metabolism)
- Rats
- Rats, Wistar
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