Intraventricular administration of recombinant tissue plasminogen activator for intraventricular hemorrhage in the newborn.

Intraventricular hemorrhage remains associated with high mortality and morbidity. Its most serious complication is posthemorrhagic hydrocephalus caused by multiple small blood clots obstructing the arachnoid villi. We treated three newborn infants (one term, two preterm) with posthemorrhagic hydrocephalus using recombinant tissue plasminogen activator, a thrombolytic agent, injected into the ventricles with a spinal needle. Sufficient fibrinolysis was achieved in these preterm patients. They all survived, and shunt surgery was only required in one. No adverse reactions or side effects have occurred. Intraventricular fibrinolysis with tissue plasminogen activator seems to be safe and effective for the treatment of intraventricular hemorrhage. However, controlled studies are needed for assessing treatment efficiency.
AuthorsMete Akisu, Mehmet Yalaz, Sertac Arslanoglu, Nilgun Kultursay
JournalNeurosurgical review (Neurosurg Rev) Vol. 26 Issue 4 Pg. 266-8 (Oct 2003) ISSN: 0344-5607 [Print] Germany
PMID12802693 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Recombinant Proteins
  • Plasminogen Activators
  • Tissue Plasminogen Activator
  • Cerebral Hemorrhage (complications, diagnosis, drug therapy)
  • Female
  • Humans
  • Hydrocephalus (diagnosis, drug therapy, etiology)
  • Infant, Newborn
  • Injections, Intraventricular
  • Male
  • Plasminogen Activators (administration & dosage)
  • Recombinant Proteins (administration & dosage)
  • Tissue Plasminogen Activator (administration & dosage)

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