Tissue hypoxia and intestinal dysbiosis in children with tuberculosis.

Abstract

We studied the role of autochthonous microflora from body cavities in the development of tissue hypoxia and instability of cell membranes. In children with tuberculosis dysbiosis manifested in nonspecific quantitative changes in the intestinal microflora and the presence of coxsackievirus antigens in the urine. DNA-containing viruses with pronounced immunosuppressive activity (e.g., herpesvirus, measles virus, and rubella virus) were found in most children. Microbiological and virological changes were accompanied by the appearance of laboratory signs for tissue hypoxia, which included inhibition of Krebs cycle dehydrogenases and alpha-glycerophosphate pathway in blood lymphocytes. Regression analysis revealed a relationship between the content of extraintestinal coxsackieviruses and inactivation of alpha-glycerophosphate dehydrogenase, succinate dehydrogenase and ratio of facultatively anaerobic bacteria in microbiocenosis, and expression of acid phosphatase and total population of malonate-positive enterobacteria, staphylococci, yeasts, and enterococci.

• Authors: M A Stenina, D A Voevodin, V D Stakhanov, O N Kisilevich, G N Rozanova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 135 Issue 2 Pg. 178-80 (Feb 2003) ISSN: 0007-4888 [Print] United States
• PMID: 12802429 (Publication Type: Journal Article)

Chemical References

• Glycerolphosphate Dehydrogenase
• Acid Phosphatase

Topics

• Acid Phosphatase (metabolism)
• Child
• Child, Preschool
• Enterobacteriaceae (metabolism)
• Enterovirus (metabolism)
• Glycerolphosphate Dehydrogenase (metabolism)
• Humans
• Hypoxia (metabolism)
• Infant
• Intestines (microbiology, virology)
• Lymphocytes (enzymology)
• Tuberculosis (microbiology, physiopathology)
• Urine (microbiology, virology)