Local expression of cytokine genes in uterine adnexa and endometrium of women with pyoinflammatory adnexal diseases.

Abstract

Changes in the local expression of IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-15, IL-18, TNF-alpha, IFN-gamma- and TGF-beta(2) genes in the uterine adnexa and endometrium were studied in women with pyoinflammatory adnexal diseases. Examination of tissue specimens from the uterine adnexa involved in inflammation revealed a direct correlation in the levels of mRNA production between IL-6 and IL-10 (r=0.93, p<0.1), IL-6 and IL-4 (r=0.96, p<0.01), IL-10 and IL-4 (r=0.91, p<0.01), IL-12 and IFN-gamma (r=0.98, p<0.01). Expression of IL-4 gene increased 5.1-fold (p=0.001), IL-6 2-fold (p=0.007), IL-8 90.2-fold (p=0.009), IL-10 2.9-fold (p=0.008), IL-12 2.3-fold (p=0.3), and TGF-beta(2) gene 10.3-fold (p=0.1). In the endometrium of women with pyoinflammatory adnexal diseases only IL-10 gene expression increased (15.6-fold, p=0.007).

• Authors: A V Zhdanov, M P Davydova, D F Kurbanova, L Yu Sosulina, T G Gabuniya, L V Van'ko, G T Sukhikh
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 135 Issue 2 Pg. 174-7 (Feb 2003) ISSN: 0007-4888 [Print] United States
• PMID: 12802428 (Publication Type: Journal Article)

Chemical References

• Cytokines

Topics

• Adnexa Uteri (immunology, physiology)
• Adnexal Diseases (genetics, immunology)
• Adult
• Cytokines (genetics, immunology)
• Endometrium (immunology, physiology)
• Female
• Humans
• Inflammation (genetics, immunology)
• Reverse Transcriptase Polymerase Chain Reaction