Abstract |
Patients with malignant glioma continue to have a dismal outcome. Those with glioblastoma multiforme, the most common type of malignant glioma, have a median survival of 40 to 60 weeks following diagnosis and only 16 to 24 weeks after recurrence. While standard therapy is surgery and external-beam radiotherapy, data indicate that chemotherapy improves the clinical outcome of some patients. Irinotecan (CPT-11, Camptosar) possesses significant activity against malignant glioma, and potentiation of this activity with combination partners, including the alkylator 1,2-bis(2-chloroethyl)-1-nitrosourea ( carmustine, BCNU), is being evaluated in an ongoing phase II study. Also, the combination of irinotecan plus temozolomide ( Temodar) has produced synergism in preclinical studies as well as encouraging responses in ongoing clinical trials. Other investigative directions include studies of irinotecan plus temozolomide and O6-benzylguanine (O6-BG) to assess the ability of O6-BG to maximize the therapeutic benefits of irinotecan combined with temozolomide.
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Authors | David A Reardon, Henry S Friedman, James B Powell Jr, Mark Gilbert, W K Yung |
Journal | Oncology (Williston Park, N.Y.)
(Oncology (Williston Park))
Vol. 17
Issue 5 Suppl 5
Pg. 9-14
(May 2003)
ISSN: 0890-9091 [Print] United States |
PMID | 12800600
(Publication Type: Journal Article, Review)
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Chemical References |
- Antimetabolites, Antineoplastic
- Antineoplastic Agents, Phytogenic
- Enzyme Inhibitors
- Irinotecan
- Fluorouracil
- Camptothecin
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Topics |
- Animals
- Antimetabolites, Antineoplastic
(therapeutic use)
- Antineoplastic Agents, Phytogenic
(administration & dosage, standards, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Camptothecin
(administration & dosage, analogs & derivatives, standards, therapeutic use)
- Colorectal Neoplasms
(drug therapy)
- Enzyme Inhibitors
(administration & dosage, standards, therapeutic use)
- Fluorouracil
(therapeutic use)
- Glioma
(drug therapy)
- Humans
- Irinotecan
- United States
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