Abstract | OBJECTIVE: Two procedures for treating major depressive disorder were compared with regard to their respective effects on mood and cognition. BACKGROUND: Fourteen patients underwent treatment with electroconvulsive therapy and 14 underwent treatment with repetitive transcranial magnetic stimulation. Patients were tested on three occasions: before initiation of treatment, at the end of treatment, and 2 weeks after the end of treatment. METHODS: Electroconvulsive therapy was applied unilaterally approximately three times per week for 2 to 4 weeks. Repetitive transcranial magnetic stimulation was applied in sessions of 1600 stimuli at 10 Hertz and 90% of motor threshold intensity to the left dorsolateral prefrontal cortex daily (Monday through Friday) for 2 consecutive weeks. RESULTS: Results indicate that electroconvulsive therapy had a more positive effect on mood than did a 2-week trial of repetitive transcranial magnetic stimulation. With regard to cognitive outcome measures, electroconvulsive therapy exerted a deleterious but transient effect on various components of memory that were no longer detected 2 weeks after the end of treatment; however, there was evidence of persistent retrograde amnesia after treatment with electroconvulsive therapy. As a group, repetitive transcranial magnetic stimulation patients experienced only a modest reduction in depression severity but there was no evidence of anterograde or retrograde memory deficits in the aftermath of treatment with repetitive transcranial magnetic stimulation. CONCLUSIONS:
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Authors | Margaret O'Connor, Cornelia Brenninkmeyer, Amy Morgan, Kerry Bloomingdale, Mark Thall, Russell Vasile, Alvaro Pascual Leone |
Journal | Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology
(Cogn Behav Neurol)
Vol. 16
Issue 2
Pg. 118-27
(Jun 2003)
ISSN: 1543-3633 [Print] United States |
PMID | 12799598
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Topics |
- Affect
- Depressive Disorder, Major
(psychology, therapy)
- Electroconvulsive Therapy
(adverse effects)
- Humans
- Memory
- Middle Aged
- Neuropsychological Tests
- Risk Assessment
- Transcranial Magnetic Stimulation
(adverse effects, therapeutic use)
- Treatment Outcome
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