Abstract | OBJECTIVE: To determine the effects of the anabolic agent oxandrolone on muscle protein and gene expression in severely burned children. SUMMARY BACKGROUND DATA: METHODS: Thirty-two severely burned children were enrolled in a prospective randomized trial. Subjects underwent studies to assess leg protein net balance 5 days after the first excision and grafting procedure. Immediately after these studies, treatment with placebo (n = 18) or 0.1 mg/kg oxandrolone (n = 14) twice a day was started. One week after this, another net balance study was performed in each subject. Body weights and total body potassium counting were used to determine body compositional changes. Muscle biopsies were taken 1 week after treatment in oxandrolone subjects to examine gene expression changes with gene array (12,600 genes). RESULTS: CONCLUSIONS:
Oxandrolone improves protein net balance and lean mass in the severely burned. These changes are associated with increased gene expression for functional muscle proteins.
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Authors | Steven E Wolf, Steven J Thomas, Mohan R Dasu, Arny A Ferrando, David L Chinkes, Robert R Wolfe, David N Herndon |
Journal | Annals of surgery
(Ann Surg)
Vol. 237
Issue 6
Pg. 801-10; discussion 810-1
(Jun 2003)
ISSN: 0003-4932 [Print] United States |
PMID | 12796576
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Amino Acids
- Anabolic Agents
- Food Additives
- Muscle Proteins
- Organic Chemicals
- Oxandrolone
- Vivonex
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Topics |
- Amino Acids
(biosynthesis)
- Anabolic Agents
(pharmacology, therapeutic use)
- Body Composition
(drug effects)
- Burns
(physiopathology, therapy)
- Child
- Food Additives
(therapeutic use)
- Food, Formulated
- Gene Expression
(drug effects)
- Humans
- Muscle Proteins
(biosynthesis)
- Oligonucleotide Array Sequence Analysis
- Organic Chemicals
- Oxandrolone
(pharmacology, therapeutic use)
- Protein Array Analysis
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