Abstract |
We report identical twin boys who each had stage IV rhabdoid tumor of the left kidney at the age of 5 months and 2 years, respectively. The 5-month-old boy, despite receiving chemotherapy, died of progressive disease at the age of 12 months. Following resection of the tumor, his twin brother was treated with 6 cycles of combination chemotherapy consisting of cisplatinum, doxorubicin, vincristine, cyclophosphamide, and actinomycin-D alternating with ifosfamide and etoposide. After complete regression of lung and brain metastases, he received high-dose thiotepa, etoposide, and cyclophosphamide, followed by autologous peripheral stem cell rescue. The patient is presently alive and free of disease 6 years posttransplant. High-dose chemotherapy followed by autologous stem cell transplant may be an effective front-line therapeutic approach for patients with metastatic rhabdoid tumor of the kidney.
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Authors | Indira Sahdev, Angelica James-Herry, Philip Scimeca, Robert Parker |
Journal | Journal of pediatric hematology/oncology
(J Pediatr Hematol Oncol)
Vol. 25
Issue 6
Pg. 491-4
(Jun 2003)
ISSN: 1077-4114 [Print] United States |
PMID | 12794530
(Publication Type: Case Reports, Journal Article, Review)
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Child, Preschool
- Combined Modality Therapy
- Diseases in Twins
- Fatal Outcome
- Humans
- Infant
- Kidney Neoplasms
(pathology, therapy)
- Male
- Peripheral Blood Stem Cell Transplantation
- Rhabdoid Tumor
(pathology, therapy)
- Transplantation, Autologous
- Treatment Outcome
- Twins, Monozygotic
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