HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Concordant rhabdoid tumor of the kidney in a set of identical twins with discordant outcomes.

Abstract
We report identical twin boys who each had stage IV rhabdoid tumor of the left kidney at the age of 5 months and 2 years, respectively. The 5-month-old boy, despite receiving chemotherapy, died of progressive disease at the age of 12 months. Following resection of the tumor, his twin brother was treated with 6 cycles of combination chemotherapy consisting of cisplatinum, doxorubicin, vincristine, cyclophosphamide, and actinomycin-D alternating with ifosfamide and etoposide. After complete regression of lung and brain metastases, he received high-dose thiotepa, etoposide, and cyclophosphamide, followed by autologous peripheral stem cell rescue. The patient is presently alive and free of disease 6 years posttransplant. High-dose chemotherapy followed by autologous stem cell transplant may be an effective front-line therapeutic approach for patients with metastatic rhabdoid tumor of the kidney.
AuthorsIndira Sahdev, Angelica James-Herry, Philip Scimeca, Robert Parker
JournalJournal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 25 Issue 6 Pg. 491-4 (Jun 2003) ISSN: 1077-4114 [Print] United States
PMID12794530 (Publication Type: Case Reports, Journal Article, Review)
Topics
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Child, Preschool
  • Combined Modality Therapy
  • Diseases in Twins
  • Fatal Outcome
  • Humans
  • Infant
  • Kidney Neoplasms (pathology, therapy)
  • Male
  • Peripheral Blood Stem Cell Transplantation
  • Rhabdoid Tumor (pathology, therapy)
  • Transplantation, Autologous
  • Treatment Outcome
  • Twins, Monozygotic

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: