Abstract |
It has been suggested that both extracellular matrix (ECM) remodeling and persistent hepatocyte injury play important roles in liver carcinogenesis process. It is, however, still controversial which factor plays a predominant role. The aim of the present study was to examine the role of each factor in the liver enzyme-altered preneoplastic lesions, focusing on the relationship between the hepatocyte injury and fibrosis extension. The effects of two similar herbal medicines ( Sho-saiko-to and Saiko-keishi-to: TJ-9 and TJ-10, respectively) were elucidated on the hepatocyte injury, fibrosis and preneoplastic lesions development using a choline-deficient-L- amino acid-defined ( CDAA) diet rat liver carcinogenesis model. TJ-9 prevented fibrosis and glutathione S-transferase placental form (GST-P)-positive preneoplastic lesion development without reducing the hepatocyte injury as indicated by the serum markers. TJ-10 significantly protected against the hepatocyte injury. However, it did not exert any inhibitory effect on fibrosis and the development of preneoplastic lesions. Our in vitro study revealed that TJ-9 markedly suppressed the hepatic stellate cell activation whereas TJ-10 did not. These results suggested that the ECM remodeling plays a more important role than the persistent hepatocyte injury in the liver enzyme-altered preneoplastic lesion development in the rat.
|
Authors | Hitoshi Yoshiji, Shigeki Kuriyama, Junichi Yoshii, Yasuhide Ikenaka, Ryuichi Noguchi, Koji Yanase, Tadashi Namisaki, Masaharu Yamazaki, Hirohisa Tsujinoue, Hiroo Imazu, Hiroshi Fukui |
Journal | Oncology reports
(Oncol Rep)
2003 Jul-Aug
Vol. 10
Issue 4
Pg. 957-62
ISSN: 1021-335X [Print] Greece |
PMID | 12792752
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Amino Acids
- Biomarkers
- Drugs, Chinese Herbal
- RNA, Messenger
- shosaiko-to
- saiko-keishi-to
- Glutathione Transferase
- Hydroxyproline
|
Topics |
- Amino Acids
(pharmacology)
- Animals
- Biomarkers
(blood)
- Carcinoma, Hepatocellular
(metabolism, pathology, prevention & control)
- Choline Deficiency
(complications)
- Diet
- Drugs, Chinese Herbal
(pharmacology)
- Extracellular Matrix
(physiology)
- Glutathione Transferase
(metabolism)
- Hydroxyproline
(metabolism)
- Liver
(drug effects, metabolism)
- Liver Cirrhosis
(enzymology, prevention & control)
- Liver Neoplasms
(metabolism, pathology, prevention & control)
- Male
- Precancerous Conditions
(metabolism, prevention & control)
- RNA, Messenger
(analysis)
- Rats
- Rats, Inbred F344
|