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Evidence for a monoamine mediated, opioid-independent, antihyperalgesic effect of venlafaxine, a non-tricyclic antidepressant, in a neurogenic pain model in rats.

AuthorsFabien Marchand, Abdelkrim Alloui, Eric Chapuy, Didier Jourdan, Teresa Pelissier, Denis Ardid, Alejandro Hernandez, Alain Eschalier
JournalPain (Pain) Vol. 103 Issue 3 Pg. 229-235 (Jun 2003) ISSN: 0304-3959 [Print] United States
PMID12791429 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Analgesics
  • Antidepressive Agents
  • Cyclohexanols
  • Enzyme Inhibitors
  • Narcotic Antagonists
  • Naloxone
  • alpha-Methyltyrosine
  • Venlafaxine Hydrochloride
  • Fenclonine
Topics
  • Analgesics (pharmacology, therapeutic use)
  • Animals
  • Antidepressive Agents (pharmacology, therapeutic use)
  • Cyclohexanols (pharmacology, therapeutic use)
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Enzyme Inhibitors (pharmacology)
  • Fenclonine (pharmacology)
  • Male
  • Mononeuropathies (drug therapy)
  • Motor Activity (drug effects)
  • Naloxone (pharmacology)
  • Narcotic Antagonists (pharmacology)
  • Pain (drug therapy)
  • Pain Threshold (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Sciatic Nerve (injuries)
  • Venlafaxine Hydrochloride
  • Vocalization, Animal (drug effects)
  • alpha-Methyltyrosine (pharmacology)

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