Acquired and developmental comorbid conditions, including language and behavioral disorders, are often associated with
epilepsy. Although the relationship between these disorders is not fully understood, their close association may indicate that they share common features, suggesting that these conditions may respond to the same
therapies. Not only has
vagus nerve stimulation (VNS)
therapy been proven to reduce the frequency of pharmacoresistant
seizures in
epilepsy patients, but preliminary studies also indicate that VNS
therapy may improve neurocognitive performance. On the basis of these findings, we hypothesized that VNS
therapy would improve the quality of life of patients with either
Landau-Kleffner syndrome (LKS) or
autism, independent of its effects on
seizures. Data were retrospectively queried from the VNS
therapy patient outcome registry (Cyberonics, Inc; Houston, TX, USA). A constant cohort of 6 LKS patients and 59 autistic patients were identified. Among the LKS patients, 3 patients at 6 months experienced at least a 50% reduction in seizure frequency as compared with baseline. Physicians reported quality-of-life improvements in all areas assessed for at least 3 of the 6 children. More than half of the patients with
autism (58%) experienced at least a 50% reduction in seizure frequency at 12 months. Improvements in all areas of quality of life monitored were reported for most patients, particularly for alertness (76% at 12 months). Although these preliminary findings are encouraging, a prospective study using standardized measurement tools specific to these disorders and a longer-term follow-up are necessary to better gauge the efficacy of VNS
therapy among these patient populations.