Abstract | BACKGROUND: A retrospective study was performed to evaluate whether pretreatment with erythropoietin and iron combined with acute preoperative normovolaemic haemodilution (APNH) could decrease homologous blood transfusion in craniosynostosis (CS) surgery. A treated group was compared with a historical group of infants who underwent surgery with no pretreatment. METHODS: The charts of 25 healthy infants who underwent CS surgery were reviewed. Nine of them underwent surgery with no treatment beforehand. Sixteen infants were given erythropoietin at a dosage of 300 U.kg -1 two times per week and iron (elemental iron 10 mg.kg-1.day-1) for 3 weeks before surgery. On the day of surgery APNH was performed after induction of general anaesthesia; a precalculated amount of autologous blood was withdrawn and replaced by hydroxyethyl starch 6%. RESULTS: Eleven of the 16 infants of the study group received only autologous blood. Five of 16 received homologous blood transfusion vs seven of nine infants in the control group. CONCLUSIONS: APNH combined with erythropoietin was effective in reducing homologous blood requirements during CS surgery. Further studies are necessary on a larger scale to assess the role of this technique in avoiding homologous blood transfusion and to evaluate how infants can benefit from this combined approach.
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Authors | Luisa Meneghini, Nicola Zadra, Vittorio Aneloni, Salvatore Metrangolo, Roberto Faggin, Franca Giusti |
Journal | Paediatric anaesthesia
(Paediatr Anaesth)
Vol. 13
Issue 5
Pg. 392-6
(Jun 2003)
ISSN: 1155-5645 [Print] France |
PMID | 12791111
(Publication Type: Journal Article)
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Chemical References |
- Hydroxyethyl Starch Derivatives
- Plasma Substitutes
- Recombinant Proteins
- Erythropoietin
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Topics |
- Anesthesia
- Blood Transfusion
- Craniosynostoses
(surgery)
- Erythropoietin
(adverse effects, therapeutic use)
- Female
- Hematocrit
- Hemodilution
- Humans
- Hydroxyethyl Starch Derivatives
(therapeutic use)
- Infant
- Male
- Plasma Substitutes
(therapeutic use)
- Preoperative Care
- Recombinant Proteins
- Retrospective Studies
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