Abstract |
Gestational vascular complications are a major cause of maternal and fetal morbidity.A growing body of evidence suggests a significant role for inherited thrombophilia in the development of gestational vascular complications. While the majority of women with thrombophilia will have an uneventful gestation, case-control studies demonstrated that thrombophilia is more prevalent in cohorts of women with pregnancy loss and early-onset pre-eclampsia. Placental abruption and severe intrauterine growth restriction (IUGR) may also be associated with thrombophilia. Placental pathological findings in women with thrombophilia are hallmarked by thrombosis and fibrin deposition potentially to a greater degree than in normal pregnancy. Preliminary non-randomized studies suggest a benefit for prophylaxis with unfractionated and low-molecular-weight heparin ( LMWH), and prospective randomized trials are in progress to define whether LMWH is effective in preventing pregnancy loss and other gestational vascular complications in women with thrombophilia and previous fetal wastage.
|
Authors | Benjamin Brenner, Michael J Kupferminc |
Journal | Best practice & research. Clinical obstetrics & gynaecology
(Best Pract Res Clin Obstet Gynaecol)
Vol. 17
Issue 3
Pg. 427-39
(Jun 2003)
ISSN: 1521-6934 [Print] Netherlands |
PMID | 12787536
(Publication Type: Journal Article, Review)
|
Chemical References |
- Heparin, Low-Molecular-Weight
|
Topics |
- Abortion, Habitual
(etiology)
- Female
- Fetal Growth Retardation
(etiology)
- Heparin, Low-Molecular-Weight
(therapeutic use)
- Humans
- Placenta Diseases
(etiology)
- Pregnancy
- Pregnancy Complications, Hematologic
- Pregnancy Outcome
- Thrombophilia
(complications, drug therapy, genetics)
|