Childhood dystonia.

Abstract

Childhood dystonias are a heterogeneous group of disorders with strong inherited basis. This review describes the clinical characteristics, classification, genetic basis, pathophysiology, biochemistry, pathology, and treatment of dystonias, including the primary dystonias, the dystonia-plus syndromes, secondary dystonias, and heredodegenerative disorders. Conditions discussed in detail include idiopathic torsion dystonia, dopa-responsive dystonia, Wilson's disease, myoclonus dystonia, rapid-onset dystonia parkinsonism, neurodegeneration with brain iron accumulation (Hallervorden-Spatz syndrome), mitochondrial dystonias, Niemann-Pick type C, and neuroacanthocytosis.

• Authors: Ergun Y Uc, Robert L Rodnitzky
• Journal: Seminars in pediatric neurology (Semin Pediatr Neurol) Vol. 10 Issue 1 Pg. 52-61 (Mar 2003) ISSN: 1071-9091 [Print] United States
• PMID: 12785748 (Publication Type: Journal Article, Review)

Topics

• Child
• Dystonia (diagnosis, drug therapy, genetics)
• Genetic Predisposition to Disease
• Humans