HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hemodynamic indices versus gastric tonometric measurements for prognosis of hemorrhagic shock: a porcine model.

Abstract
The aim of the study reported here was to assess the prognostic value of gastric tonometry and its implications in the initial phases of hemorrhagic shock. Hemorrhagic shock was induced by use of femoral arterial bleeding in 12 hybrid swine under general anesthesia. Approximately 30% of the circulating blood volume was removed, until mean arterial pressure of 45 mmHg was reached. The shock conditions were observed over a limited period (90 min) by comparing traditional hemodynamic parameters with gastric tonometric measurements and tissue oxygenation. After a shock period of 90 min without pharmacologic treatment, blood was collected in acid-citrate dextrose-treated bags and was reinfused via the right femoral vein. At the end of the experiment, seven animals had good hemodynamic recovery on reinfusion (group A), whereas values in five animals deceased in the same phase (group B). Hemodynamic and gastric tonometric results were compared between survivors and nonsurvivors. Intravascular volume restoration and reduction of systemic vascular resistance (SVR) enabled the animals of group A to maintain standard ventricular kinetics and recover in terms of splanchnic regional flow. In addition, increase in intramucosal gastric pH (pHi), decrease in the pH-gap (pHa-Hi), and progressive restoration in gastric wall tissue oxygenation (PtO2) also were observed. These results suggest that useful diagnostic and therapeutic indications can be obtained by acquisition of simple hemodynamic measurements at the beginning of the shock period. On the basis of results of statistical analysis, only mean arterial pressure and SVR were good indicators of shock development, whereas pHi was not a significant factor in this experimental model.
AuthorsLucia Martini, Gianluca Giavaresi, Milena Fini, Stefano Faenza, Flavia Petrini, Roberto Giardino
JournalComparative medicine (Comp Med) Vol. 53 Issue 2 Pg. 178-85 (Apr 2003) ISSN: 1532-0820 [Print] United States
PMID12784852 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Oxygen
Topics
  • Animals
  • Blood Pressure
  • Blood Volume
  • Disease Models, Animal
  • Female
  • Gastric Mucosa (metabolism)
  • Hemodynamics
  • Hydrogen-Ion Concentration
  • Manometry
  • Oximetry
  • Oxygen (analysis)
  • Prognosis
  • Regional Blood Flow
  • Shock, Hemorrhagic (pathology, physiopathology)
  • Splanchnic Circulation
  • Stomach (physiopathology)
  • Swine

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: