Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As?

Abstract

Melanin-concentrating hormone (MCH) is orexigenic (stimulates food intake). Two receptors for MCH have been identified in humans, MCH1-R and MCH2-R. SNAP-7941 is a small molecule MCH1-R antagonist. SNAP-7941 inhibits MCH-induced food intake in rats. SNAP-7941 alone reduced weight gain in young growing rats and in mature rats fed a high-fat diet. Preliminary testing with SNAP7941 in animal models of depression and anxiety shows it has antidepressant and anxiolytic effects. SNAP7941 should undergo further development as an anorectic, antidepressant and anxiolytic.

• Authors: Sheila A Doggrell
• Journal: Expert opinion on investigational drugs (Expert Opin Investig Drugs) Vol. 12 Issue 6 Pg. 1035-8 (Jun 2003) ISSN: 1354-3784 [Print] England
• PMID: 12783607 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Anxiety Agents
• Antidepressive Agents
• Appetite Depressants
• Hypothalamic Hormones
• Melanins
• Piperidines
• Pituitary Hormones
• Pyrimidines
• SNAP7941
• melanin-concentrating hormone

Topics

• Animals
• Anti-Anxiety Agents (chemistry, pharmacology, therapeutic use)
• Antidepressive Agents (chemistry, pharmacology, therapeutic use)
• Appetite Depressants (chemistry, pharmacology, therapeutic use)
• Drug Evaluation, Preclinical (methods)
• Humans
• Hypothalamic Hormones (antagonists & inhibitors, metabolism)
• Melanins (antagonists & inhibitors, metabolism)
• Piperidines (chemistry, pharmacology, therapeutic use)
• Pituitary Hormones (antagonists & inhibitors, metabolism)
• Pyrimidines (chemistry, pharmacology, therapeutic use)