Abstract |
Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.
|
Authors | Michael D Urbaniak, Lisa M Frost, John P Bingham, Lloyd R Kelland, John A Hartley, Derek N Woolfson, Stephen Caddick |
Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 13
Issue 12
Pg. 2025-7
(Jun 16 2003)
ISSN: 0960-894X [Print] England |
PMID | 12781188
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibiotics, Antineoplastic
- Cyclopentanes
- Enediynes
- neocarzinostatin chromophore
- Zinostatin
- cyclopentenone
|
Topics |
- Antibiotics, Antineoplastic
(chemical synthesis, chemistry, pharmacology)
- Cell Line, Tumor
- Cyclopentanes
(chemistry, pharmacology)
- Drug Screening Assays, Antitumor
- Enediynes
- HT29 Cells
- Humans
- Hydroxylation
- Inhibitory Concentration 50
- K562 Cells
- Zinostatin
(analogs & derivatives, chemical synthesis, chemistry, pharmacology)
|