Abstract |
1. Kryptopyrrole (2,4-dimethyl-3-ethyl pyrrole) was shown to elevate the urinary porphyrin excretion and the hepatic content of porphyrins in the rat. The simultaneous administration of sigma-aminolaevulinic acid increased these effects. 2. Kryptopyrrole was present in the urine of patients with hereditary hepatic porphyria, in attack and in remission, but not in those with latent porphyria.
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Authors | M J Brodie, D J Graham, G G Thompson, M R Moore, A Goldberg |
Journal | Clinical science and molecular medicine
(Clin Sci Mol Med)
Vol. 50
Issue 5
Pg. 431-4
(May 1976)
ISSN: 0301-0538 [Print] England |
PMID | 1277751
(Publication Type: Journal Article)
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Chemical References |
- Porphyrins
- Pyrroles
- Aminolevulinic Acid
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Topics |
- Aminolevulinic Acid
(metabolism)
- Animals
- Humans
- Male
- Porphyrias
(genetics, urine)
- Porphyrins
(pharmacology)
- Pyrroles
(pharmacology, urine)
- Rats
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