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The porphyrinogenic effects of kryptopyrrole in the rat and the occurrence of urinary kryptopyrrole in human hereditary hepatic porphyria.

Abstract
1. Kryptopyrrole (2,4-dimethyl-3-ethyl pyrrole) was shown to elevate the urinary porphyrin excretion and the hepatic content of porphyrins in the rat. The simultaneous administration of sigma-aminolaevulinic acid increased these effects. 2. Kryptopyrrole was present in the urine of patients with hereditary hepatic porphyria, in attack and in remission, but not in those with latent porphyria.
AuthorsM J Brodie, D J Graham, G G Thompson, M R Moore, A Goldberg
JournalClinical science and molecular medicine (Clin Sci Mol Med) Vol. 50 Issue 5 Pg. 431-4 (May 1976) ISSN: 0301-0538 [Print] England
PMID1277751 (Publication Type: Journal Article)
Chemical References
  • Porphyrins
  • Pyrroles
  • Aminolevulinic Acid
Topics
  • Aminolevulinic Acid (metabolism)
  • Animals
  • Humans
  • Male
  • Porphyrias (genetics, urine)
  • Porphyrins (pharmacology)
  • Pyrroles (pharmacology, urine)
  • Rats

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