Effect of microsomal triglyceride transfer protein gene polymorphism in the promoter region on dyslipidemia in type 2 diabetic subjects.

Abstract

OBJECTIVE:

To explore the relationship between microsomal triglyceride transfer protein (MTP) gene variation and diabetic dyslipidemia among Chinese.

METHODS:

Using PCR restriction fragment length polymorphism (PCR-RFLP) analysis and gene sequencing, we studied the influence of a common MTP gene polymorphism in the promoter region on the apoB-containing lipoproteins in 44 Chinese type 2 diabetic subjects and 32 non-diabetic volunteers.

RESULTS:

A common functional G/T polymorphism in 493 bp upstream from the transcriptional start point was detected among native Chinese. There were 41 carriers (53.9%) of the MTP-493 G/G genotype, 28 (36.8%) of the MTP-493 G/T genotype and 7 (9.3%) of the MTP-493 T/T genotype. The allele frequency of MTP-493 T in the diabetic group was 0.30. The MTP-493 T/T diabetic group had significantly higher TG (P < 0.05), VLDL-CH (P < 0.05) and smaller LDL particle size (P < 0.001) than the MTP-493 common genotype group.

CONCLUSION:

Genetic variation in the MTP promoter is likely to be highly involved in the production of dyslipidemia in type 2 diabetic subjects.

• Authors: Liming Chen, Gen Yoshino, Eiichi Maeda, Shufan Zeng
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 116 Issue 2 Pg. 215-7 (Feb 2003) ISSN: 0366-6999 [Print] China
• PMID: 12775233 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carrier Proteins
• microsomal triglyceride transfer protein

Topics

• Carrier Proteins (genetics)
• Diabetes Mellitus, Type 2 (genetics)
• Genotype
• Humans
• Hyperlipidemias (etiology, genetics)
• Polymorphism, Genetic
• Promoter Regions, Genetic