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[The effect of shourong compound formula on levels of dopamine and its metabolites in brain of Parkinson's disease mice induced by reserpine].

AbstractOBJECTIVE:
To investigate the effect of Shourong compound formula on treating Parkinson's disease.
METHOD:
Parkinson's disease model mice induced by reserpine was used and by HPLC-ED the levels of Dopamine (DA) and its metabolites were determined.
RESULT:
Madopar could increase the levels of DA in brain of PD mice. The effect of madopar together with Sourong compound formula was better than that of madopar(P < 0.001).
CONCLUSION:
Shourong compound formula together with madopar has synergic effect on increase of DA level in brain and can reduce clinic dose of madopar so that side effect of madopar can be decreased.
AuthorsWei Wang, De-zhong Zhao, Xiao-fang Sun, Sheng-dong Gu
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 27 Issue 5 Pg. 368-70 (May 2002) ISSN: 1001-5302 [Print] China
PMID12774329 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Drug Combinations
  • Drugs, Chinese Herbal
  • Plant Extracts
  • benserazide, levodopa drug combination
  • shourong compound formula
  • 3,4-Dihydroxyphenylacetic Acid
  • Levodopa
  • Benserazide
  • Reserpine
  • Dopamine
  • Homovanillic Acid
Topics
  • 3,4-Dihydroxyphenylacetic Acid (metabolism)
  • Animals
  • Benserazide (pharmacology)
  • Brain (metabolism)
  • Dopamine (metabolism)
  • Drug Combinations
  • Drug Synergism
  • Drugs, Chinese Herbal (isolation & purification, pharmacology)
  • Homovanillic Acid (metabolism)
  • Levodopa (pharmacology)
  • Male
  • Mice
  • Parkinson Disease, Secondary (chemically induced, metabolism)
  • Plant Extracts (pharmacology)
  • Plants, Medicinal (chemistry)
  • Reserpine

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