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Efficacy of a herbal preparation in patients with functional dyspepsia: a meta-analysis of double-blind, randomized, clinical trials.

Abstract
A meta-analysis was performed of double-blind, randomized clinical studies that evaluated the efficacy of the herbal preparation Iberogast in patients with functional dyspepsia. All studies had the same duration and used the same dosage of active treatment and the same primary outcome measure, a dyspepsia-specific gastrointestinal symptom score. Of the 592 trial participants, 196 were treated with Iberogast and 192 with placebo or cisapride (positive control). The individual studies all showed a substantial improvement of symptoms with Iberogast but varying results regarding its statistically significant superiority to placebo. The meta-analysis of all studies, however, demonstrated a clear, highly significant overall therapeutic effect of Iberogast in the treatment of functional dyspepsia. Tolerability of the preparation was excellent.
AuthorsKarl-Josef Gundermann, Erhard Godehardt, Marianne Ulbrich
JournalAdvances in therapy (Adv Ther) 2003 Jan-Feb Vol. 20 Issue 1 Pg. 43-9 ISSN: 0741-238X [Print] United States
PMID12772817 (Publication Type: Comparative Study, Journal Article, Meta-Analysis)
Chemical References
  • Plant Extracts
  • iberogast
  • Cisapride
Topics
  • Adult
  • Aged
  • Cisapride (therapeutic use)
  • Double-Blind Method
  • Dyspepsia (diagnosis, drug therapy)
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Patient Satisfaction
  • Phytotherapy (methods)
  • Plant Extracts (therapeutic use)
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Sensitivity and Specificity
  • Treatment Outcome

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