Technology evaluation: reticulose, advanced viral research.

Abstract

Advanced Viral Research Corp is developing reticulose, a nontoxic peptide nucleic acid preparation, for the potential treatment of viral infection. The compound is undergoing phase II clinical trials for the potential topical treatment of human papillomavirus infection in the US. Reticulose has also been investigated in clinical studies for the treatment of HIV infection in Barbados. Additionally, the drug is being investigated for the potential treatment of adenovirus infection, and is being evaluated in adjuvant arthritis models by the Weizmann Institute of Science. Investigations into the use of reticulose to reduce the toxic effects of cancer treatment are underway in Israel. Phase I trials in patients with cachexia associated with HIV, lymphoma and solid tumor, have also been initiated in Israel.

• Authors: Wuyi Wang
• Journal: Current opinion in molecular therapeutics (Curr Opin Mol Ther) Vol. 5 Issue 2 Pg. 186-91 (Apr 2003) ISSN: 1464-8431 [Print] England
• PMID: 12772510 (Publication Type: Journal Article, Review)

Chemical References

• Antiviral Agents
• EOM613
• Peptide Nucleic Acids

Topics

• Antiviral Agents (chemical synthesis, metabolism, pharmacology, therapeutic use)
• Chromatography, High Pressure Liquid
• Clinical Trials, Phase I as Topic
• Clinical Trials, Phase II as Topic
• Humans
• Peptide Nucleic Acids (chemical synthesis, chemistry, metabolism, pharmacology, therapeutic use)