Abstract | BACKGROUND AND OBJECTIVES: METHODS: RESULTS: The benign lesions were consistently negative for Apo D, whereas 3 of the 8 "in situ" melanomas (37.5%) and 12 of the 32 invasive melanomas (37.5%) showed positive immunostaining for Apo D. The percentage of Apo D-positive tumors was significantly higher in nodular than in superficial spreading melanomas (P = 0.011) and in melanomas with vertical growth phase than in melanomas with radial growth phase (P = 0.02). In addition, the percentage of Apo D-positive tumors was positively and significantly correlated with Clark's level of invasion (P = 0.046). CONCLUSIONS:
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Authors | Eva Miranda, Francisco Vizoso, Arancha Martín, Isabel Quintela, María Daniela Corte, María Eugenia Seguí, Iratxe Ordiz, Antonio Martínez Merino |
Journal | Journal of surgical oncology
(J Surg Oncol)
Vol. 83
Issue 2
Pg. 99-105
(Jun 2003)
ISSN: 0022-4790 [Print] United States |
PMID | 12772203
(Publication Type: Journal Article)
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Copyright | Copyright 2003 Wiley-Liss, Inc. |
Chemical References |
- Apolipoproteins
- Apolipoproteins D
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Apolipoproteins
(biosynthesis)
- Apolipoproteins D
- Child
- Female
- Humans
- Immunohistochemistry
- Male
- Melanoma
(metabolism, pathology)
- Middle Aged
- Neoplasm Invasiveness
- Prognosis
- Skin Neoplasms
(metabolism, pathology)
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