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Apolipoprotein D expression in cutaneous malignant melanoma.

AbstractBACKGROUND AND OBJECTIVES:
Apolipoprotein D (Apo D) is a protein component of the human plasma lipid transport system, and an androgen-regulated protein in both breast and prostate cancer cell lines. Our goal was to evaluate the expression of Apo D in malignant cutaneous melanomas, as well as to assess its possible relationship to clinical and pathological parameters.
METHODS:
Apo D expression was analyzed in 32 paraffin-embedded tissues from patients with invasive cutaneous malignant melanomas, in 8 samples from in situ melanoma, and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi, and 2 dysplastic melanocytic nevi), using immunohistochemical techniques.
RESULTS:
The benign lesions were consistently negative for Apo D, whereas 3 of the 8 "in situ" melanomas (37.5%) and 12 of the 32 invasive melanomas (37.5%) showed positive immunostaining for Apo D. The percentage of Apo D-positive tumors was significantly higher in nodular than in superficial spreading melanomas (P = 0.011) and in melanomas with vertical growth phase than in melanomas with radial growth phase (P = 0.02). In addition, the percentage of Apo D-positive tumors was positively and significantly correlated with Clark's level of invasion (P = 0.046).
CONCLUSIONS:
Apo D may be a new prognostic factor of unfavorable evolution in cutaneous malignant melanoma.
AuthorsEva Miranda, Francisco Vizoso, Arancha Martín, Isabel Quintela, María Daniela Corte, María Eugenia Seguí, Iratxe Ordiz, Antonio Martínez Merino
JournalJournal of surgical oncology (J Surg Oncol) Vol. 83 Issue 2 Pg. 99-105 (Jun 2003) ISSN: 0022-4790 [Print] United States
PMID12772203 (Publication Type: Journal Article)
CopyrightCopyright 2003 Wiley-Liss, Inc.
Chemical References
  • Apolipoproteins
  • Apolipoproteins D
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Apolipoproteins (biosynthesis)
  • Apolipoproteins D
  • Child
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Melanoma (metabolism, pathology)
  • Middle Aged
  • Neoplasm Invasiveness
  • Prognosis
  • Skin Neoplasms (metabolism, pathology)

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