Abstract | PURPOSE: MATERIALS AND METHODS:
Cystatin C, beta-trace protein and serum creatinine in children who underwent routine measurement of glomerular filtration rate were obtained in a prospective study. A spina bifida group (27 measurements in 27 patients 1.4 to 20.0 years old, 15 female, 12 male) was compared with a group of controls (211 measurements in 201 patients with various other renal pathologies 1.0 to 20.2 years old, 89 female, 122 male). All patients underwent nuclear medicine clearance investigations with 99mtechnetium diethylenetetraminepentaacetic acid. Z scores were calculated for body mass index, height and weight. Receiver operating characteristic (ROC) analysis and ROC plots were done to assess their diagnostic accuracy. RESULTS: Serum creatinine and the Schwartz formula did not correlate with glomerular filtration rate in the patients with spina bifida. Correlation coefficients for cystatin C were 0.45 and 0.84 in the spina bifida and control groups, respectively, while correlation coefficients for beta-trace protein were 0.31 and 0.75, respectively. For both groups ROC area was highest for cystatin C (up to 0.97 ROC area in control group). CONCLUSIONS:
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Authors | Anne Pham-Huy, Michael Leonard, Nathalie Lepage, Jacqueline Halton, Guido Filler |
Journal | The Journal of urology
(J Urol)
Vol. 169
Issue 6
Pg. 2312-5
(Jun 2003)
ISSN: 0022-5347 [Print] United States |
PMID | 12771788
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- CST3 protein, human
- Cystatin C
- Cystatins
- Cysteine Proteinase Inhibitors
- Lipocalins
- Radiopharmaceuticals
- Creatinine
- Intramolecular Oxidoreductases
- prostaglandin R2 D-isomerase
- Technetium Tc 99m Pentetate
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Topics |
- Adolescent
- Adult
- Biomarkers
(blood)
- Body Mass Index
- Child
- Child, Preschool
- Creatinine
(blood)
- Cystatin C
- Cystatins
(blood)
- Cysteine Proteinase Inhibitors
(blood)
- Female
- Glomerular Filtration Rate
- Humans
- Infant
- Intramolecular Oxidoreductases
(blood)
- Kidney Diseases
(physiopathology)
- Lipocalins
- Male
- ROC Curve
- Radiopharmaceuticals
- Sensitivity and Specificity
- Spinal Dysraphism
(blood, physiopathology)
- Technetium Tc 99m Pentetate
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