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Treatment improves serotonin transporter binding and reduces binge eating.

AbstractRATIONALE:
Serotonin (5-HT) is involved in the control of eating behaviour by inhibiting food intake. Obese women with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding.
OBJECTIVES:
The aim of this study was to investigate the effect of a successful treatment on 5-HT transporters in OB-BED.
METHODS:
The 5-HT transporter binding of seven OB-BED was measured by single-photon emission computed tomography (SPECT), by using iodine-123-labelled nor-beta-CIT as a tracer, before treatment and after successful treatment, when the OB-BED were asymptomatic. Treatment consisted of group psychotherapy and fluoxetine medication. The control subjects, six obese women without eating disorders, were also studied twice by using SPECT.
RESULTS:
The 5-HT transporter binding of the symptomatically recovered OB-BED increased significantly (24+/-22%) after treatment, whereas in the control group, binding remained unchanged.
CONCLUSIONS:
The results tentatively suggest that 5-HT transporter binding in OB-BED is an adaptive mechanism, which can be affected by treatment. Furthermore, there seems to be a link between improved 5-HT transporter binding and reduced binge eating.
AuthorsLiisa I Tammela, Aila Rissanen, Jyrki T Kuikka, Leila J Karhunen, Kim A Bergström, Eila Repo-Tiihonen, Hannu Naukkarinen, Esko Vanninen, Jari Tiihonen, Matti Uusitupa
JournalPsychopharmacology (Psychopharmacology (Berl)) Vol. 170 Issue 1 Pg. 89-93 (Oct 2003) ISSN: 0033-3158 [Print] Germany
PMID12768277 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carrier Proteins
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin Uptake Inhibitors
  • Fluoxetine
  • Serotonin
Topics
  • Adult
  • Bulimia (diagnostic imaging, metabolism, therapy)
  • Carrier Proteins (metabolism)
  • Female
  • Fluoxetine (pharmacology, therapeutic use)
  • Humans
  • Membrane Glycoproteins (metabolism)
  • Membrane Transport Proteins
  • Mesencephalon (metabolism)
  • Nerve Tissue Proteins
  • Protein Binding
  • Psychotherapy
  • Serotonin (metabolism)
  • Serotonin Plasma Membrane Transport Proteins
  • Selective Serotonin Reuptake Inhibitors (pharmacology, therapeutic use)
  • Time Factors
  • Tomography, Emission-Computed, Single-Photon

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