Abstract | RATIONALE:
Serotonin (5-HT) is involved in the control of eating behaviour by inhibiting food intake. Obese women with binge-eating disorder (OB-BED) were recently found to have reduced 5-HT transporter binding. OBJECTIVES: The aim of this study was to investigate the effect of a successful treatment on 5-HT transporters in OB-BED. METHODS: The 5-HT transporter binding of seven OB-BED was measured by single-photon emission computed tomography (SPECT), by using iodine-123-labelled nor-beta-CIT as a tracer, before treatment and after successful treatment, when the OB-BED were asymptomatic. Treatment consisted of group psychotherapy and fluoxetine medication. The control subjects, six obese women without eating disorders, were also studied twice by using SPECT. RESULTS: The 5-HT transporter binding of the symptomatically recovered OB-BED increased significantly (24+/-22%) after treatment, whereas in the control group, binding remained unchanged. CONCLUSIONS: The results tentatively suggest that 5-HT transporter binding in OB-BED is an adaptive mechanism, which can be affected by treatment. Furthermore, there seems to be a link between improved 5-HT transporter binding and reduced binge eating.
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Authors | Liisa I Tammela, Aila Rissanen, Jyrki T Kuikka, Leila J Karhunen, Kim A Bergström, Eila Repo-Tiihonen, Hannu Naukkarinen, Esko Vanninen, Jari Tiihonen, Matti Uusitupa |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 170
Issue 1
Pg. 89-93
(Oct 2003)
ISSN: 0033-3158 [Print] Germany |
PMID | 12768277
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- SLC6A4 protein, human
- Serotonin Plasma Membrane Transport Proteins
- Serotonin Uptake Inhibitors
- Fluoxetine
- Serotonin
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Topics |
- Adult
- Bulimia
(diagnostic imaging, metabolism, therapy)
- Carrier Proteins
(metabolism)
- Female
- Fluoxetine
(pharmacology, therapeutic use)
- Humans
- Membrane Glycoproteins
(metabolism)
- Membrane Transport Proteins
- Mesencephalon
(metabolism)
- Nerve Tissue Proteins
- Protein Binding
- Psychotherapy
- Serotonin
(metabolism)
- Serotonin Plasma Membrane Transport Proteins
- Selective Serotonin Reuptake Inhibitors
(pharmacology, therapeutic use)
- Time Factors
- Tomography, Emission-Computed, Single-Photon
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