Ringer's ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis.

Abstract

Reactive species of oxygen have been implicated as being important mediators in a variety of pathologic conditions, including burns, various forms of ischemia/reperfusion injury, and hemorrhagic shock. Pyruvate, an intermediate in the metabolism of glucose, is a potent reactive species of oxygen scavenger. Pyruvate, however, is unstable in aqueous solutions, and has not been developed as a therapeutic agent. Ethyl pyruvate, a simple derivative of the parent compound, is thought to be more stable in solution. Ringer's ethyl pyruvate solution (REPS) has been evaluated in a number of preclinical studies using animal models of mesenteric ischemia/reperfusion injury, hemorrhagic shock, and acute endotoxemia. Treatment with REPS, when compared with treatment with Ringer's lactate solution, has been shown to be able to improve survival and decrease expression of proinflammatory mediators. REPS warrants further evaluation for the resuscitation of patients with hemorrhagic shock.

• Authors: Mitchell P Fink
• Journal: The Journal of trauma (J Trauma) Vol. 54 Issue 5 Suppl Pg. S141-3 (May 2003) ISSN: 0022-5282 [Print] United States
• PMID: 12768116 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Review)

Chemical References

• Isotonic Solutions
• Ringer's ethyl pyruvate

Topics

• Fluid Therapy (methods)
• Humans
• Isotonic Solutions (therapeutic use)
• Resuscitation (methods)
• Sepsis (drug therapy)
• Shock, Hemorrhagic (drug therapy)