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Complete remission induced by G-CSF in a patient with acute myeloid leukemia with t(8;21)(q22;q22).

Abstract
We describe a case of acute myeloid leukemia (AML) with t(8;21) in which complete remission (CR) was obtained with G-CSF given at 10 microg/kg in the absence of concomitant cytotoxic chemotherapy. CR was achieved following 2 weeks of therapy and confirmed by investigating minimal residual disease by four-color flow cytometry analysis. During treatment with G-CSF, maturing cells with cytoplasmic Auer Rods were observed in the peripheral blood, suggesting a differentiation effect. This case adds further evidence for a specific role of G-CSF in the treatment of AML with t(8;21), namely in patients who are not eligible for aggressive chemotherapy.
AuthorsFelicetto Ferrara, Ettore Mariano Schiavone, Salvatore Palmieri, Giuseppina Mele, Barbara Pocali, Giulia Scalia, Paolo Morabito, Lucia Sebastio, Luigi Del Vecchio
JournalThe hematology journal : the official journal of the European Haematology Association / EHA (Hematol J) Vol. 4 Issue 3 Pg. 218-21 ( 2003) ISSN: 1466-4860 [Print] England
PMID12764355 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Granulocyte Colony-Stimulating Factor
Topics
  • Acute Disease
  • Bone Marrow (pathology)
  • Chromosomes, Human, Pair 21
  • Chromosomes, Human, Pair 8
  • Female
  • Flow Cytometry
  • Granulocyte Colony-Stimulating Factor (therapeutic use)
  • Humans
  • Immunophenotyping
  • Leukemia, Myeloid (diagnosis, drug therapy, genetics)
  • Middle Aged
  • Molecular Diagnostic Techniques
  • Remission Induction
  • Salvage Therapy
  • Translocation, Genetic
  • Treatment Outcome

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