Complete remission induced by G-CSF in a patient with acute myeloid leukemia with t(8;21)(q22;q22).

Abstract

We describe a case of acute myeloid leukemia (AML) with t(8;21) in which complete remission (CR) was obtained with G-CSF given at 10 microg/kg in the absence of concomitant cytotoxic chemotherapy. CR was achieved following 2 weeks of therapy and confirmed by investigating minimal residual disease by four-color flow cytometry analysis. During treatment with G-CSF, maturing cells with cytoplasmic Auer Rods were observed in the peripheral blood, suggesting a differentiation effect. This case adds further evidence for a specific role of G-CSF in the treatment of AML with t(8;21), namely in patients who are not eligible for aggressive chemotherapy.

• Authors: Felicetto Ferrara, Ettore Mariano Schiavone, Salvatore Palmieri, Giuseppina Mele, Barbara Pocali, Giulia Scalia, Paolo Morabito, Lucia Sebastio, Luigi Del Vecchio
• Journal: The hematology journal : the official journal of the European Haematology Association (Hematol J) Vol. 4 Issue 3 Pg. 218-21 ( 2003) ISSN: 1466-4860 [Print] England
• PMID: 12764355 (Publication Type: Case Reports, Journal Article)

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Acute Disease
• Bone Marrow (pathology)
• Chromosomes, Human, Pair 21
• Chromosomes, Human, Pair 8
• Female
• Flow Cytometry
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Humans
• Immunophenotyping
• Leukemia, Myeloid (diagnosis, drug therapy, genetics)
• Middle Aged
• Molecular Diagnostic Techniques
• Remission Induction
• Salvage Therapy
• Translocation, Genetic
• Treatment Outcome