Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone.

Abstract

The identification of a safe, orally active iron chelator is critically important for the prevention of morbidity and early death in patients receiving regular red cell transfusions. Based on our findings in a 1-year multicenter, prospective study of the safety and efficacy of deferiprone in patients with thalassemia major, we have extended the treatment period to 4 years. The mean dose of the chelator was 73 mg/kg per day during 531 patient-years. The rates of agranulocytosis (absolute neutrophil count [ANC] < 500 x 10(9)/L) and milder forms of neutropenia (ANC, 500-1500 x 10(9)/L) were 0.2 and 2.8 per 100 patient-years, respectively. Neutropenia occurred significantly more commonly in patients with intact spleens. Gastrointestinal and joint symptoms decreased significantly after the first year of therapy, and led to discontinuation of deferiprone in only one patient in years 2 to 4. The mean alanine aminotransferase (ALT) value of 71 U/L after 4 years of therapy was significantly higher than the baseline value of 61 U/L. Trend analysis showed no increase in the ALT levels or the percentage of patients with ALT levels greater than twice the upper limit of the reference range. Ferritin levels did not change significantly from the values at the time of change from deferoxamine to deferiprone in either the intention-to-treat analysis or in the 84 patients who completed 4 years of therapy. Because of concerns regarding the effectiveness of the studied dose of deferiprone, 47 patients discontinued therapy, whereas 15 patients interrupted therapy because of concerns regarding low iron levels. The results of this study help to define the safety and effectiveness of long-term therapy with deferiprone.

• Authors: Alan R Cohen, Renzo Galanello, Antonio Piga, Vincenzo De Sanctis, Fernando Tricta
• Journal: Blood (Blood) Vol. 102 Issue 5 Pg. 1583-7 (Sep 01 2003) ISSN: 0006-4971 [Print] United States
• PMID: 12763939 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Iron Chelating Agents
• Pyridones
• Deferiprone
• Ferritins
• Alanine Transaminase

Topics

• Administration, Oral
• Adolescent
• Adult
• Agranulocytosis (chemically induced)
• Alanine Transaminase (blood)
• Child
• Deferiprone
• Ferritins (blood)
• Gastrointestinal Diseases (chemically induced)
• Humans
• Iron Chelating Agents (administration & dosage, adverse effects)
• Joint Diseases (chemically induced)
• Neutropenia (chemically induced)
• Patient Dropouts
• Prospective Studies
• Pyridones (administration & dosage, adverse effects)
• Treatment Outcome
• beta-Thalassemia (drug therapy)