Abstract |
The dopamine D(3) receptor agonist PD 128907 decreased body temperature in the rat. The selective dopamine D(3) and D(4) receptor antagonists, A-437203 and L-745,870, respectively, did not prevent this effect. In contrast, PD 128907-induced hypothermia was antagonized by SCH 23390, a selective D(1) receptor antagonist, and by L-741,626, a selective D(2) receptor antagonist. Moreover, the selective D(2) receptor agonist trihydroxy-N-n-propylnoraporphine (TNPA) elicited a robust hypothermia which was prevented by pretreatment with L-741,626 but not by A-437203. In agreement with previous data obtained in D(3) knock-out mice, present results suggest that D(2) rather than D(3) receptors mediate dopamine receptor agonist- induced hypothermia in rats. In addition, it appears that both D(1) and D(2) receptors may be involved in a cooperative manner.
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Authors | F Chaperon, M D Tricklebank, L Unger, H C Neijt |
Journal | Neuropharmacology
(Neuropharmacology)
Vol. 44
Issue 8
Pg. 1047-53
(Jun 2003)
ISSN: 0028-3908 [Print] England |
PMID | 12763098
(Publication Type: Journal Article)
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Chemical References |
- 2-(3-(4-(2-tert-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1-yl)propylsulfanyl)-3H-pyrimidin-4-one fumarate
- 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine
- Aporphines
- Benzazepines
- Benzopyrans
- Dopamine Agonists
- Dopamine Antagonists
- Drd3 protein, rat
- Drd4 protein, rat
- Indoles
- Oxazines
- Piperazines
- Piperidines
- Pyridines
- Pyrimidines
- Pyrroles
- Receptors, Dopamine D1
- Receptors, Dopamine D2
- Receptors, Dopamine D3
- 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol
- Receptors, Dopamine D4
- 2,10,11-trihydroxy-N-n-propylnoraporphine
- 3-(4-(4-chlorophenyl-4-hydroxypiperidino)methyl)indole
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Topics |
- Animals
- Aporphines
(pharmacology)
- Benzazepines
(pharmacology)
- Benzopyrans
(pharmacology)
- Body Temperature Regulation
(drug effects, physiology)
- Dopamine Agonists
(pharmacology)
- Dopamine Antagonists
(pharmacology)
- Hypothermia
(chemically induced, physiopathology)
- Indoles
(pharmacology)
- Oxazines
(pharmacology)
- Piperazines
(pharmacology)
- Piperidines
(pharmacology)
- Pyridines
(pharmacology)
- Pyrimidines
(pharmacology)
- Pyrroles
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Dopamine D1
(drug effects, physiology)
- Receptors, Dopamine D2
(drug effects, physiology)
- Receptors, Dopamine D3
- Receptors, Dopamine D4
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