Abstract |
Follicular mucinosis is a tissue reaction pattern characterized by mucin deposition with follicular sebaceous units and is found as an idiopathic, primary, benign process ( alopecia mucinosa), or as a secondary process due to inflammatory and neoplastic disorders ( mycosis fungoides). When associated with follicular mucinosis, mycosis fungoides commonly pursues an aggressive course, often undergoing large-cell transformation, which is associated with resistance to therapy and poor prognosis. We present a case of mycosis fungoides with follicular mucinosis that was treated with incomplete courses of interferon, isotretinoin, and polychemotherapy with subsequent rapid progression to tumor-stage mycosis fungoides with large cell transformation and nodal and bone marrow involvement. In this setting, the patient was treated with local radiation therapy, total-skin electron beam therapy, and therapy and maintenance with the oral retinoid-X-receptor retinoid bexarotene, and achieved a durable complete remission.
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Authors | Narin Apisarnthanarax, Chul S Ha, Madeleine Duvic |
Journal | American journal of clinical dermatology
(Am J Clin Dermatol)
Vol. 4
Issue 6
Pg. 429-33
( 2003)
ISSN: 1175-0561 [Print] New Zealand |
PMID | 12762834
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticarcinogenic Agents
- Tetrahydronaphthalenes
- Bexarotene
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Topics |
- Administration, Oral
- Adult
- Anticarcinogenic Agents
(therapeutic use)
- Bexarotene
- Cell Transformation, Neoplastic
(drug effects, pathology, radiation effects)
- Chemotherapy, Adjuvant
- Female
- Humans
- Mucinosis, Follicular
(etiology, pathology, therapy)
- Mycosis Fungoides
(complications, pathology, therapy)
- Skin Neoplasms
(complications, pathology, therapy)
- Tetrahydronaphthalenes
(therapeutic use)
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