Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits.

Abstract

There are no effective therapeutics for treating invasive Scedosporium prolificans infections. Doses of 15, 25, and 50 mg/kg of body weight/day for the new triazole albaconazole (ABC) were evaluated in an immunocompetent rabbit model of systemic infection with this mold. Treatments were begun 1 day after challenge and given for 10 days. ABC at any dose was more effective than amphotericin B (AMB) at 0.8 mg/kg/day at clearing S. prolificans from tissue (P < 0.007). The percentages of survival at 25 mg of ABC/kg/day were similar to those obtained with AMB. Rabbits showed 100% survival when they were treated with 50 mg of ABC per kg (P < 0.0001 versus control group), and only this dosage was able to reduce tissue burden significantly in the five organs studied, i.e., spleen, kidneys, liver, lungs, and brain.

• Authors: Javier Capilla, Clara Yustes, Emili Mayayo, Belkys Fernández, Montserrat Ortoneda, F Javier Pastor, Josep Guarro
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 47 Issue 6 Pg. 1948-51 (Jun 2003) ISSN: 0066-4804 [Print] United States
• PMID: 12760872 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Quinazolines
• Triazoles
• albaconazole

Topics

• Animals
• Antifungal Agents (pharmacology)
• Male
• Mycetoma (drug therapy, microbiology)
• Quinazolines (pharmacology)
• Rabbits
• Scedosporium (growth & development, metabolism)
• Survival Analysis
• Triazoles (pharmacology)