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A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia.

Abstract
A possible means of rapid cooling in the emergency treatment of malignant hyperpyrexia, peritoneal dialysis using a cold dialysate, is described. Experimental observations in a young man on a regular peritoneal dialysis regime showed that significant heat extraction can be obtained when either a cool (20 degrees C) or cold (9 degrees C) dialysis fluid is used. The maximum heat exchange observed was 17.5 kJ/min when 2 litre of cold dialysis was instilled for a mean time of 10 min. This rate of heat exchange is within the 10--40 kJ/min range of excess heat production that occurs in malignant hyperpyrexia. Since peritoneal dialysis is, technically, a very quick and simple procedure, it is suggested that it might play a very useful role in the emergency treatment of malignant hyperpyrexia. The dialysis treatment would also correct some of the biochemical disturbances that occur in this condition.
AuthorsJ Gjessing, J Barsa, P J Tomlin
JournalBritish journal of anaesthesia (Br J Anaesth) Vol. 48 Issue 5 Pg. 469-73 (May 1976) ISSN: 0007-0912 [Print] England
PMID1276020 (Publication Type: Journal Article)
Topics
  • Anesthesia, General (adverse effects)
  • Emergencies
  • Humans
  • Malignant Hyperthermia (therapy)
  • Peritoneal Dialysis
  • Temperature

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