Single-dose therapy for giardiasis in school-age children.

A randomized controlled trial was carried out to study the efficacy of combined albendazole and praziquantel in the treatment of giardiasis in school-age children. Eighty-four children were randomly allocated to 3 groups: group 1 (n = 31) albendazole 400 mg combined with praziquantel 20 mg/kg; group 2 (n = 26) albendazole 800 mg as a single dose; group 3 (n = 27) tinidazole 50 mg/kg as a single dose. The treatment was considered curative when Giardia was not found in two consecutive stool samples. The parasitological cure rate was 74.2% for combined single-dose albendazole-praziquantel, 50% and 92.6% in the albendazole and tinidazole groups respectively (p = 0.0023). There was no statistically significant difference between the cure rates of the combined regimen and tinidazole (p > 0.05). This combined regimen was considered safe, with only minor side-effects being observed. Of the single-dose regimens, tinidazole still achieves the highest parasitological cure rate for giardiasis. The albendazole-praziquantel combined regimen may be an alternative single-dose therapy for giardiasis in children, especially as this combination will eradicate common intestinal protozoa and co-existing helminths. Whether the dosage of this combination treatment should be adjusted for G. intestinalis remains to be established by further study.
AuthorsKrisana Pengsaa, Kriengsak Limkittikul, Chanathep Pojjaroen-anant, Keswadee Lapphra, Chukiat Sirivichayakul, Pataraporn Wisetsing, Panida Nantha-aree, Pornthep Chanthavanich
JournalThe Southeast Asian journal of tropical medicine and public health (Southeast Asian J Trop Med Public Health) Vol. 33 Issue 4 Pg. 711-7 (Dec 2002) ISSN: 0125-1562 [Print] Thailand
PMID12757214 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Anthelmintics
  • Antiprotozoal Agents
  • Tinidazole
  • Praziquantel
  • Albendazole
  • Albendazole (therapeutic use)
  • Analysis of Variance
  • Anthelmintics (therapeutic use)
  • Antiprotozoal Agents (therapeutic use)
  • Child
  • Directly Observed Therapy
  • Drug Therapy, Combination
  • Endemic Diseases (prevention & control, statistics & numerical data)
  • Feces (parasitology)
  • Female
  • Giardiasis (diagnosis, drug therapy, epidemiology, parasitology)
  • Humans
  • Male
  • Nutritional Status
  • Parasite Egg Count
  • Praziquantel (therapeutic use)
  • Students
  • Thailand (epidemiology)
  • Tinidazole (therapeutic use)
  • Treatment Outcome
  • Urban Health (statistics & numerical data)

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