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Melanoma chemoprevention: a role for statins or fibrates?

Abstract
Although numerous second-generation isoprenylation inhibitors are proposed or under investigation for the treatment and/or prevention of cancer (eg, R115777, SCH 66336, L-778,123, BMS-214662), the chemotherapeutic and chemopreventive potential of commonly prescribed first-generation isoprenylation inhibitors, the statins, and other classes of lipid-lowering medications, the fibrates, has yet to be seriously explored. Two lipid-lowering medications, lovastatin and gemfibrozil, have been associated with a decreased incidence of melanoma in large, prospective, randomized, double-blind, placebo-controlled clinical cardiology trials. This article reviews melanoma biology and the clinical evidence for the use of lipid-lowering medications for melanoma chemoprevention and/or adjuvant chemotherapy.
AuthorsRobert P Dellavalle, M Kelly Nicholas, Lisa M Schilling
JournalAmerican journal of therapeutics (Am J Ther) 2003 May-Jun Vol. 10 Issue 3 Pg. 203-10 ISSN: 1075-2765 [Print] United States
PMID12756427 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Anticarcinogenic Agents
  • Anticholesteremic Agents
  • Antineoplastic Agents
  • Lovastatin
  • Gemfibrozil
Topics
  • Anticarcinogenic Agents (therapeutic use)
  • Anticholesteremic Agents (therapeutic use)
  • Antineoplastic Agents (therapeutic use)
  • Chemoprevention (methods)
  • Gemfibrozil (therapeutic use)
  • Humans
  • Lovastatin (therapeutic use)
  • Melanoma (drug therapy, prevention & control)
  • Meta-Analysis as Topic
  • Prospective Studies
  • Randomized Controlled Trials as Topic

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