[Treatment of intracranial germ cell tumours and other tumours of the pineal region].

Abstract

The management of patients with central nervous system germ-cell tumours is evolving, and a definitive standard has not been achieved. A large amount of data indicate that radiotherapy alone results in long-term relapse free survival rates of about 90% in patients with germinoma. Various prospective trials evaluated the results of combinations of chemotherapy and reduced dose and/or volume radiotherapy. The survival rates of combined treatment approaches were similar to the rates achieved with craniospinal radiotherapy alone. Nevertheless, the relapse rates were probably higher due to the significant number of relapses that arouse outside the volume treated with radiotherapy. Additional studies are necessary to determine the appropriate radiotherapy volumes and the role of combined treatments. Chemotherapy alone results in high relapse rates and can not be recommended. Mature teratomas are benign germ cell tumours that can be controlled with complete surgical resection in over 90% of cases. Non-germinoma germ cell tumours are a heterogeneous group of tumours that includes very aggressive tumours such as mixed and pure choriocarcinomas, yolk sac tumours, and embryonal carcinomas; and tumours with intermediate aggressiveness such as mixed tumours with germinoma and teratoma, immature teratomas and teratomas with malignant transformation. Both radiotherapy alone and chemotherapy alone result in quite low rates of tumour control and current treatment approaches include chemotherapy and radiotherapy, with surgical removal of the tumour in some patients. Pineocytomas are benign tumours that are controlled in most cases by complete surgical resection or partial surgical resection and local field irradiation. Current treatment approaches for pineoblastomas include surgery, chemotherapy, and craniospinal irradiation with a local boost. Chemotherapy alone was used to delay irradiation in infants with very little success.

• Authors: C A Regueiro
• Journal: Neurocirugia (Asturias, Spain) (Neurocirugia (Astur)) Vol. 14 Issue 2 Pg. 127-39 (Apr 2003) ISSN: 1130-1473 [Print] Spain
• Vernacular Title: Tratamiento de los tumores germinales intracraneales y otros tumores de la región pineal.
• PMID: 12754642 (Publication Type: English Abstract, Journal Article, Review)

Topics

• Brain Neoplasms (radiotherapy, surgery)
• Humans
• Neoplasms, Germ Cell and Embryonal (radiotherapy, surgery)
• Pineal Gland (radiation effects, surgery)
• Pinealoma (radiotherapy, surgery)
• Radiation Dosage