Abstract | OBJECTIVE: METHODS: Holtzman rats were used. Animals were anesthetized with tribromoethanol (20 mg) per 100 grams of body weight, ip. A stainless steel guide cannula was implanted into the MSA and PVN. All drugs were injected in 0.5-microl volumes for 10-15 seconds. Seven days after brain surgery, water and 3% NaCl intake, urine and sodium excretion, and arterial blood pressure were measured. RESULTS:
Losartan (40 nmol) and [Sar1, Ala8] ANG II (40 nmol) completely eliminated whereas PD 123319 (40 nmol) partially blocked the increase in water and sodium intake and the increase in arterial blood pressure induced by ANG II (10 nmol) injected into the MSA. The PVN administration of PD 123319 and [Sar1, Ala8] ANG II blocked whereas losartan attenuated the diuresis and natriuresis induced by MSA administration of ANG II. CONCLUSION: MSA involvement with PVN on water and sodium homeostasis and arterial pressure modulation utilizing ANGII receptors is suggested.
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Authors | Wilson Abrão Saad, Luiz Antonio de Arruda Camargo |
Journal | Arquivos brasileiros de cardiologia
(Arq Bras Cardiol)
Vol. 80
Issue 4
Pg. 396-405
(Apr 2003)
ISSN: 0066-782X [Print] Brazil |
PMID | 12754560
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin Receptor Antagonists
- Antihypertensive Agents
- Imidazoles
- Pyridines
- Vasoconstrictor Agents
- Angiotensin II
- PD 123319
- Sodium
- Saralasin
- Losartan
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Topics |
- Angiotensin II
(pharmacology)
- Angiotensin Receptor Antagonists
- Animals
- Antihypertensive Agents
(pharmacology)
- Blood Pressure
(drug effects)
- Diuresis
(drug effects)
- Drinking
(drug effects)
- Homeostasis
- Imidazoles
(pharmacology)
- Losartan
(pharmacology)
- Male
- Paraventricular Hypothalamic Nucleus
- Pyridines
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Saralasin
(pharmacology)
- Septum of Brain
- Sodium
(metabolism)
- Vasoconstrictor Agents
(pharmacology)
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