[Contribution of linezolid to the treatment of complicated infections of the skin and soft tissues].

Abstract

THREE GROUPS OF INCREASING SEVERITY: According to the 2000 consensus conference, bacterial infections of the skin and soft tissues can be classified in three categories of increasing severity: bacterial dermo-hypodermal infections, bacterial dermo-hypodermal necrotizing infections, necrotizing fasciitis. The last two categories are medicosurgical emergency conditions requiring repeated surgical debridement and probabilistic antibiotic therapy. LINEZOLID: The clinical efficacy of linezolid in bacterial infections of the skin and soft tissues is comparable to that of oxacillin/dicloxacillin. Several arguments (frequent implication of Streptococcus pyogenes and Staphylococcus aureus, well-adapted spectrum, changing resistance pattern of Gram-positive cocci, efficacy against associated bacteriemia, favorable kinetics and diffusion data in cutaneous tissues) argue in favor of the use of linezolid in infections of the skin and soft tissues

• Authors: Rémy Gauzit
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 32 Issue 13 Pt 2 Pg. S17-20 (Apr 05 2003) ISSN: 0755-4982 [Print] France
• Vernacular Title: Apport du linézolide dans le traitement des infections compliquées de la peau et des tissus mous.
• PMID: 12754445 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Acetamides
• Anti-Infective Agents
• Oxazolidinones
• Penicillins
• Linezolid
• Oxacillin

Topics

• Acetamides (therapeutic use)
• Anti-Infective Agents (therapeutic use)
• Controlled Clinical Trials as Topic
• France (epidemiology)
• Humans
• Linezolid
• Oxacillin (therapeutic use)
• Oxazolidinones (therapeutic use)
• Penicillins (therapeutic use)
• Skin Diseases, Bacterial (drug therapy, epidemiology)
• Soft Tissue Infections (drug therapy, epidemiology)