Abstract | OBJECTIVE: STUDY DESIGN: Postmenopausal women with osteopenia who were otherwise healthy were assigned randomly in a double blind-fashion to receive placebo (n = 16 women) or raloxifene (60 mg/d, n = 16 women). Before and after 4 months, the blood pressure of each woman was monitored every 30 minutes for 41 hours with the use of an ambulatory device. RESULTS: Similar to the placebo outcome, the raloxifene administration did not modify 24-hour daytime (7 AM -11 PM) and nighttime (11 PM -7 AM) blood pressure and heart rate values. Day-night differences and the 24-hour rhythmic variation of mean blood pressure, which was evaluated by cosinor analysis, were also not affected by placebo or by raloxifene. CONCLUSION:
Raloxifene does not influence 24-hour blood pressure of postmenopausal women. These data are reassuring for the cardiovascular safety of the long-term raloxifene administration.
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Authors | Angelo Cagnacci, Anna Lisa Zanni, Annibale Volpe |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 188
Issue 5
Pg. 1278-82
(May 2003)
ISSN: 0002-9378 [Print] United States |
PMID | 12748498
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Placebos
- Selective Estrogen Receptor Modulators
- Raloxifene Hydrochloride
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Topics |
- Blood Pressure
(drug effects)
- Blood Pressure Monitoring, Ambulatory
- Circadian Rhythm
- Double-Blind Method
- Female
- Heart Rate
(drug effects)
- Humans
- Middle Aged
- Osteoporosis, Postmenopausal
(drug therapy, physiopathology)
- Placebos
- Raloxifene Hydrochloride
(administration & dosage)
- Selective Estrogen Receptor Modulators
(administration & dosage)
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