Can hTERT peptide (540-548) -specific CD8 T cells recognize and kill tumor cells?

Abstract

This commentary reviews the data on HLA-A2-restricted CD8 T cells specific for peptide (540-548) derived from hTERT (human telomerase reverse transcriptase). Several studies have reported the successful generation of such T cells (1, 2, 3). However, tumor recognition was observed in some, but not all, studies. More data are required to elucidate whether hTERT peptide (540-548) -specific T cells can indeed recognize and destroy tumor cells. It would be highly useful if telomerase would emerge as a universal tumor antigen that can be targeted in the cancer immunotherapy of HLA-A2 positive patients.

• Authors: Daniel E Speiser, Jean-Charles Cerottini, Pedro Romero
• Journal: Cancer immunity (Cancer Immun) Vol. 2 Pg. 14 (Oct 14 2002) ISSN: 1424-9634 [Electronic] United States
• PMID: 12747759 (Publication Type: Journal Article, Review)

Chemical References

• Peptide Fragments
• telomerase reverse transcriptase (540-548)
• Telomerase

Topics

• CD8-Positive T-Lymphocytes (cytology, immunology)
• Cytotoxicity, Immunologic
• Humans
• Neoplasms (enzymology, immunology, pathology)
• Peptide Fragments (immunology)
• T-Lymphocytes, Cytotoxic (cytology, immunology)
• Telomerase (immunology)