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Improving the mouse model for studying the efficacy of voriconazole.

Abstract
Outbred ICR mice were rendered neutropenic, infected intravenously with Fusarium solani and treated orally with voriconazole. When given alone, voriconazole was not protective up to 40 mg/kg/day. When grapefruit juice was administered before infection, mice were protected by voriconazole. The mechanism may be inhibition of gut mucosal cytochrome enzymes that rapidly degrade voriconazole in the mouse. These murine studies support expansion of voriconazole therapy in other highly resistant systemic mycoses.
AuthorsJohn R Graybill, Laura K Najvar, Gloria M Gonzalez, Steve Hernandez, Rosie Bocanegra
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 51 Issue 6 Pg. 1373-6 (Jun 2003) ISSN: 0305-7453 [Print] England
PMID12746374 (Publication Type: Journal Article)
Chemical References
  • Pyrimidines
  • Triazoles
  • Voriconazole
Topics
  • Animals
  • Beverages
  • Citrus paradisi
  • Disease Models, Animal
  • Fusarium (drug effects, growth & development)
  • Kidney (drug effects, microbiology)
  • Mice
  • Mice, Inbred ICR
  • Mycoses (drug therapy, microbiology)
  • Pyrimidines (pharmacology, therapeutic use)
  • Spleen (drug effects, microbiology)
  • Triazoles (pharmacology, therapeutic use)
  • Voriconazole

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